Viglimet 850 mg

Viglimet is a combination oral medication designed to effectively manage type 2 diabetes mellitus (T2DM). It combines two powerful anti-hyperglycemic agents, Vildagliptin and Metformin Hydrochloride, to help control blood sugar levels in adults. This dual-action formulation targets multiple pathways involved in glucose regulation, offering enhanced glycemic control compared to monotherapy.

Active Ingredients:

1. Vildagliptin: A dipeptidyl peptidase-4 (DPP-4) inhibitor that improves pancreatic function. By inhibiting DPP-4, Vildagliptin increases the levels of incretin hormones (GLP-1 and GIP), which stimulate insulin release from pancreatic beta cells and suppress glucagon secretion from alpha cells, especially during meals.
2. Metformin Hydrochloride: A biguanide that primarily reduces hepatic glucose production. It also improves peripheral insulin sensitivity, facilitating better glucose uptake in muscle and fat tissues, and slows glucose absorption in the intestines.

Benefits:

• Dual Mechanism of Action: Provides complementary effects by addressing insulin resistance, hepatic glucose production, and beta-cell dysfunction.
• Effective Glycemic Control: Helps achieve and maintain target HbA1c levels.
• Weight Neutrality: Unlike other anti-diabetic drugs, Viglimet is generally weight-neutral or may promote slight weight loss.
• Reduced Risk of Hypoglycemia: The mechanism minimizes the likelihood of low blood sugar levels.

Indications:
Viglimet is prescribed for adults with type 2 diabetes mellitus who require a combination of Vildagliptin and Metformin to achieve optimal glycemic control. It is particularly beneficial for patients inadequately controlled on monotherapy or lifestyle interventions alone.

Dosage and Administration:

• Dose is individualized based on the patient’s medical condition and response to therapy.
• Typically taken twice daily with meals to minimize gastrointestinal side effects.

Precautions:

• Not suitable for patients with type 1 diabetes or diabetic ketoacidosis.
• Use with caution in patients with renal or hepatic impairment.

Conclusion:
Viglimet is a convenient and effective option for managing type 2 diabetes, combining the benefits of two proven agents to ensure comprehensive glycemic control